1ClassyLady 68F
3126 posts
4/13/2020 3:22 pm
Doctors and nurses need PPE, patients need ventilators

Even as the U.S. saw some of the highest daily death rates from COVID-19 last week, there were hopeful signs that the epidemic may be peaking in some places, including New York City. However, Health experts have warned about reopening the country too early. Antibody testing could be one indicator of immunity, but how long that immunity lasts is an open question.

Harvard medical students have used their free time to create a coronavirus curriculum. How the ventilator shortage could be compounded by a shortage of specialized doctors and nurses and shortage of PPE for Healthcare professionals.

Everyday New York state governor, Andrew Cuomo reports daily confirmed coronavirus cases and death toll around 700 daily in New York state. There are not enough PPE for doctors and nurses to protect them. PPE is difficult to put on and take-off when they need to use the toilets, layer and layer of PPE. But they don't have sufficient of N95 masks, gloves and protective gowns. Doctors reduce to drink water and have meals, so less often to use toilet. Doctors don't have time to eat or drink. I am very worried about my as a MD in New York.

Doctors have to make decision who to use the ventilator, who doesn't. Of course, doctors would like to save all the patients, but who is stronger and have better chance to live get the ventilator. Actually ventilators are not the cure or a treatment of coronavirus. Ventilator is just help patient to breath. Doctors are human and seeing patients died are heartbroken for them, but they need to get over the sad mood and take care the next patient. Do you know how their feeling? Doctors don't have time to cry and patient's family can't say good-bye to the patient even burial ceremony.

During the weekend, I read an article "Compassionate Use of Remdesivir for Patients with Severe Covid-19" posted on New England Journal of Medicine. Let me explain the abstract of that article. Among 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57% ) were receiving mechanical ventilation and 4 (8% ) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68% ) had an improvement in oxygen-support class, including 17 of 30 patients (57% ) receiving mechanical ventilation who were extubated. A total of 25 patients (47% ) were discharged, and 7 patients (13% ) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.

Conclusions

In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use Remdesivir, clinical improvement was observed in 36 of 53 patients (68% ). Measurement of efficacy will require ongoing randomized, placebo-controlled trials of Remdesivir therapy. (Funded by Gilead Sciences.)




Honesty is the best policy.


1ClassyLady 68F
3289 posts
4/14/2020 1:57 pm

    Quoting  :

Although Trump is not perfect, but at least he is anti-communists, CCP and W.H.O.

Can you ask your Australian prime minister to do the way you want? Can a British citizen ask their British prime minister to do the way they want? Same as not every American can ask Trump do the way they want? It is impassible that citizen can contact president or prime minister....



Honesty is the best policy.


1ClassyLady 68F
3289 posts
4/13/2020 7:32 pm

1) Sufficient PPE for MD and nurses as priority - Don't let doctors wear trash bags as protective gowns, trash bags are easy to break, no protection. Not enough N95 masks and surgical masks, doctor only get one N95 mask a day. Not enough specialized "Thoracic" doctor and used other doctors to treat Covit -19 patients. Many doctors and nurses died on treating patients and infected Covit-19.

2) Not enough testing kits - Even doctors and nurses not getting testing kits for themselves. Doctors and Nurses can't have "social distancing" but very close to check patient's lungs, throat, .... where the virus exist. I just heard from TV news that South Korea is shipping 5 minutes testing kits to USA today. (finally)

3) Treatment (drug) - Remdesivir. Can Gilead Sciences lower the price? Saving lives.

4) Ventilators (help to breath) by MedTronic. Trump asked GM, Ford and Tesla to make ventilators but Tesla made ventilators failed on quality. None of Tesla made ventilators can be used. Mr. Elon Musk can go on Space, making electric cars, but not ventilator.

5) Vaccine - by Regeneron. It take time, a year or 18 months to test on animals and blind test on human. I have Flu shot every year in winter. I have NEVER had Pneumonia vaccine yet.

We need those five things..... Meanwhile, we need to put on masks, gloves and keep social distancing. We can't enjoy a meal at restaurants but take-out only. 24hr Fitness closed, retail stores lack of customers, banks closed earlier, employees have been laid-off, ....



Honesty is the best policy.


1ClassyLady 68F
3289 posts
4/13/2020 4:02 pm

I have been Taiwan and California licensed pharmacist for most of my life. I have had both retail pharmacy and Kaiser hospital pharmacy experiences. Hospital in-patients are more serious than retail out-patients.

I would trust Remdesivir over HydroxyChloroQuine. President Trump has different opinion with Dr. Anthony Fauci and tweeted that he wants to fire Dr. Fauci. HydorxyChloroQuine was approved by FDA use for Malaria, not for Coronavirus. I posted this blog to show you that Remdesivir has more promising effectiveness. Dr. Fauci is a MD, Trump is a politician.

Remdesivir is a large and complicate molecular and difficult to synthesize it. That is why only U.S. Gilead Sciences can compound. China has tried but only compounded few mg, Taiwan also compounded few mg. Remdesivir is expensive and needs at least 10 days therapy.

Hope you can understand more about Remdesivir that I read from New England Journal of Medicine. So far, it is a more promising drug for Covid-19.



Honesty is the best policy.